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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

[Pathophysiology of heart failure]

Arturo Méndez Ortiz1

  • 1Médico adjunto, Cardiología Adultos 3 piso, INCICH, Tlalpan, DF México. Mendez_Arturo@yahoo.com

Archivos De Cardiologia De Mexico
|October 5, 2006
PubMed

Insights

Current heart failure treatments targeting neuroendocrine activation offer mid-term benefits but eventually become less effective. This review explores alternative pathways and preventive strategies for advanced heart failure management.

Area of Science:

  • Cardiology
  • Pharmacology
  • Pathophysiology

Context:

  • Established heart failure therapies target neuroendocrine activation, providing initial benefits.
  • Agents like ACE inhibitors, beta-blockers, and spironolactone have demonstrated efficacy in clinical trials.
  • Despite these advances, heart failure often progresses to terminal stages, indicating limitations in current treatment paradigms.

Purpose:

  • To review pathophysiologic pathways beyond neuroendocrine activation in heart failure.
  • To explore potential preventive measures for heart failure.
  • To inform the integration of novel strategies into standardized heart failure treatment.

Summary:

  • Current heart failure treatments, while effective in the mid-term by counteracting neuroendocrine effects, face limitations as the disease progresses.
  • This review examines alternative pathophysiologic mechanisms driving heart failure progression.
  • It proposes the incorporation of new preventive strategies into existing treatment protocols.

Impact:

  • Highlights the need for evolving heart failure treatment beyond current standards.
  • Suggests novel therapeutic targets and preventive approaches for improved patient outcomes.
  • Aims to reduce disease progression and mortality in advanced heart failure stages.

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