The incidence of abnormal pattern electroretinography in optic nerve demyelination

This report describes the pattern electroretinogram (PERG) findings in 141 patients with optic nerve demyelination in one or both eyes. The overall incidence of PERG abnormality in the 199 eyes with abnormally delayed pattern visual evoked potential (PVEP) P100 component was 39.2%, with 84.6% of these PERG abnormalities being confined to the N95 component. The incidence of abnormal PERG was greater (53.3%) in those eyes with a history of retrobulbar neuritis than in those with sub-clinical demyelination (22.8%). The importance of stimulus parameters is noted. The value of the PERG in the improved interpretation of an abnormal PVEP is discussed.