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Hemoglobin A2 and F in patients with psoriasis
N Zlatkov1, L Damianova, K Prodanov
1Institute of Dermatology and Venerology, Medical Academy, Sofia.
Dermatologische Monatschrift
|January 1, 1990
Summary
This study found elevated levels of Hemoglobin A2 (HbA2) and Hemoglobin F (HbF) in various psoriasis forms. These findings suggest potential genetic disturbances in globine chain synthesis in psoriasis patients.
Area of Science:
- Dermatology
- Hematology
- Genetics
Background:
- Psoriasis is a chronic inflammatory skin condition with diverse clinical presentations.
- Hemoglobin variants, such as HbA2 and HbF, are indicators of red blood cell health and potential genetic factors.
Purpose of the Study:
- To investigate the levels of Hemoglobin A2 (HbA2) and Hemoglobin F (HbF) in patients with different forms of psoriasis.
- To explore potential correlations between these hemoglobin variants and psoriasis subtypes.
Main Methods:
- Analysis of HbA2 and HbF levels in 91 patients diagnosed with various psoriasis forms.
- Categorization of patients based on psoriasis type: vulgaris placata, generalisata/erythroderma, psoriatic arthritis, and pustulosa.
Main Results:
- A statistically significant increase in HbA2 was observed in patients with restricted psoriasis (psoriasis vulgaris placata) and psoriatic arthritis.
- Hemoglobin F (HbF) levels were found to be statistically significantly increased across all studied forms of psoriasis.
Conclusions:
- The study suggests a probable disturbance in globine chain synthesis in psoriasis.
- This disturbance is likely genetically dependent, as indicated by altered HbA2 and HbF levels in different psoriasis phenotypes.