Related Experiment Video
Updated: Jan 23, 2026

Characterization of pH-Dependent Reversible Self-Assembly of Amyloid Beta 1-40-Coated Gold Colloids
Published on: March 21, 2025
Amyloid beta peptide, 4-hydroxynonenal and apoptosis
Mark A Lovell1, William R Markesbery
1Department of Chemistry, University of Kentucky, Lexington, KY 40536, USA. malove2@uky.edu
Abstract:
Considerable evidence suggests a role for oxidative stress in the pathogenesis of neuron degeneration in several neurodegenerative disorders including Alzheimer's disease (AD). Although debated, increasing evidence suggests that oxidative stress/damage (amyloid beta peptide, iron/hydrogen peroxide) or neurotoxic by-products of lipid peroxidation (4-hydroxy-2-nonenal, acrolein) lead to cell death through apoptosis or programmed cell death in AD. This review discusses current evidence supporting the role of oxidative stress/damage mediated apoptosis in in vitro models of neurodegeneration.
More Related Videos
Related Concept Videos
Amyloid Fibrils
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Amyloid Fibrils
Apoptosis
Peptide Bonds
Dipeptidyl Peptidase 4 Inhibitors
Piaget's Stage 4 of Cognitive Development
Abstract Reasoning and Hypothetical-Deductive Thinking
Unlike the concrete operational...

