Related Experiment Video
Updated: Jan 23, 2026
08:53
Characterization of pH-Dependent Reversible Self-Assembly of Amyloid Beta 1-40-Coated Gold Colloids
Published on: March 21, 2025
1.2K
Amyloid beta peptide, 4-hydroxynonenal and apoptosis
Mark A Lovell1, William R Markesbery
1Department of Chemistry, University of Kentucky, Lexington, KY 40536, USA. malove2@uky.edu
Current Alzheimer Research
|October 5, 2006
Summary
Oxidative stress and its toxic by-products contribute to neuron degeneration in Alzheimer's disease (AD). This review examines evidence for oxidative stress-mediated apoptosis in in vitro AD models.
Area of Science:
- Neuroscience
- Cell Biology
- Biochemistry
Background:
- Oxidative stress is implicated in neurodegenerative disorders like Alzheimer's disease (AD).
- Key contributors include amyloid beta peptide, iron/hydrogen peroxide, and lipid peroxidation by-products (4-hydroxy-2-nonenal, acrolein).
Purpose of the Study:
- To review evidence supporting the role of oxidative stress in AD pathogenesis.
- To focus on oxidative stress-mediated apoptosis in in vitro models.
Main Methods:
- Literature review of in vitro studies on neurodegeneration.
- Analysis of mechanisms linking oxidative stress/damage to apoptosis in AD models.
Main Results:
- Evidence suggests oxidative stress and specific toxic by-products induce apoptosis in neuronal cells.
- In vitro models demonstrate the link between oxidative damage and programmed cell death.
Conclusions:
- Oxidative stress-mediated apoptosis is a significant factor in AD neurodegeneration.
- In vitro studies provide valuable insights into these mechanisms.
More Related Videos
Related Concept Videos
03:03Amyloid Fibrils
11.7K
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
11.7K
03:03Amyloid Fibrils
6.4K
No description available
6.4K
01:30Apoptosis
14.2K
Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
14.2K
02:43Peptide Bonds
82.5K
A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
82.5K
01:23Dipeptidyl Peptidase 4 Inhibitors
614
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
614
01:19Piaget's Stage 4 of Cognitive Development
596
The formal operational stage, as described in Piaget's cognitive development theory, begins around age 11 and extends into adulthood. It marks the emergence of advanced cognitive abilities that differentiate adolescent and adult thinking from those of younger children. This stage is characterized by abstract reasoning, hypothetical-deductive reasoning, and a more complex understanding of self and others.
Abstract Reasoning and Hypothetical-Deductive Thinking
Unlike the concrete operational...
Abstract Reasoning and Hypothetical-Deductive Thinking
Unlike the concrete operational...
596