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Related Experiment Video

Updated: Jul 19, 2026

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome

Published on: September 23, 2015

Selective agents for serotonin2C (5-HT2C) receptor.

Enza Lacivita¹, Marcello Leopoldo

¹Università degli Studi di Bari, Dipartimento Farmaco-Chimico, via Orabona, 4, 70125, Bari, Italy.

Current Topics in Medicinal Chemistry

|October 5, 2006

Summary

This review covers selective serotonin 2C (5-HT2C) receptor agonists and antagonists, focusing on their synthesis, characterization, and structure-activity relationships for conditions like appetite, depression, and substance abuse.

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Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram

Published on: November 27, 2016

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Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome

Published on: September 23, 2015

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram

Published on: November 27, 2016

Area of Science:

Neuroscience
Pharmacology
Medicinal Chemistry

Background:

The serotonin 2C (5-HT2C) receptor is implicated in various neurological and psychiatric conditions.
Its involvement spans appetite regulation, depression, obsessive-compulsive disorder (OCD), panic disorders, and substance abuse.

Purpose of the Study:

To review the synthesis and characterization of selective 5-HT2C receptor agonists and antagonists.
To highlight structure-activity relationships of these compounds.

Main Methods:

Comprehensive literature search of non-patent and patent sources up to November 2005.
Analysis of reported synthetic routes and characterization data for 5-HT2C receptor modulators.

Main Results:

Identification and summary of various selective 5-HT2C receptor agonists and antagonists.
Discussion of structure-activity relationships where available in the literature.

Conclusions:

The review provides a consolidated overview of 5-HT2C receptor ligands.
It serves as a resource for researchers in medicinal chemistry and pharmacology focused on 5-HT2C receptor targets.