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Related Concept Videos

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However, invadopodia can...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Catenins01:23

Catenins

Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the adherens...

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Related Experiment Video

Updated: Jun 20, 2026

Reconstitution Of &#946;-catenin Degradation In Xenopus Egg Extract
09:41

Reconstitution Of β-catenin Degradation In Xenopus Egg Extract

Published on: June 18, 2014

Unwinding a path to nuclear beta-catenin.

Xi He1

  • 1Program of Neurobiology, Children's Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115 USA. xi.he@childrens.harvard.edu

Cell
|October 5, 2006
PubMed
Summary

Platelet-derived growth factor (PDGF) triggers c-Abl kinase to phosphorylate p68 RNA helicase, promoting cell transition. This phosphorylation releases beta-catenin, enhancing nuclear signaling independently of Wnt.

Area of Science:

  • Cell biology
  • Molecular mechanisms
  • Signal transduction

Background:

  • Epithelial-mesenchymal transition (EMT) is crucial for development and disease.
  • Beta-catenin signaling is a key pathway in cell adhesion and gene regulation.
  • The Axin destruction complex normally limits beta-catenin availability.

Discussion:

  • Platelet-derived growth factor (PDGF) induces EMT.
  • PDGF activates c-Abl kinase, leading to p68 RNA helicase phosphorylation.
  • Phosphorylated p68 disrupts the Axin destruction complex, freeing beta-catenin.

Key Insights:

  • PDGF-induced EMT is mediated by c-Abl kinase and p68 RNA helicase.
  • p68 RNA helicase acts as a novel regulator of beta-catenin stability.
  • Nuclear beta-catenin signaling can be promoted independently of Wnt pathway activation.

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An Immunofluorescent Method for Characterization of Barrett&#8217;s Esophagus Cells
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An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells

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Biotinylated Cell-penetrating Peptides to Study Intracellular Protein-protein Interactions
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Biotinylated Cell-penetrating Peptides to Study Intracellular Protein-protein Interactions

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Related Experiment Videos

Last Updated: Jun 20, 2026

Reconstitution Of &#946;-catenin Degradation In Xenopus Egg Extract
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Reconstitution Of β-catenin Degradation In Xenopus Egg Extract

Published on: June 18, 2014

An Immunofluorescent Method for Characterization of Barrett&#8217;s Esophagus Cells
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An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells

Published on: July 20, 2014

Biotinylated Cell-penetrating Peptides to Study Intracellular Protein-protein Interactions
10:26

Biotinylated Cell-penetrating Peptides to Study Intracellular Protein-protein Interactions

Published on: December 20, 2017

Outlook:

  • Understanding this pathway could reveal new therapeutic targets for cancer and fibrosis.
  • Further research into p68 RNA helicase function in different cellular contexts is warranted.
  • Investigating the interplay between growth factors and Wnt-independent signaling is crucial.