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Related Concept Videos

Long-term Potentiation01:35

Long-term Potentiation

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Preparation of Synaptoneurosomes from Mouse Cortex using a Discontinuous Percoll-Sucrose Density Gradient
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Dendritic protein synthesis, synaptic plasticity, and memory.

Michael A Sutton1, Erin M Schuman

  • 1Division of Biology 114-96, California Institute of Technology, Howard Hughes Medical Institute, Pasadena, CA 91125, USA.

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|October 5, 2006
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Summary
This summary is machine-generated.

New protein synthesis in neuronal dendrites is crucial for long-term memory formation. This review explores the evidence supporting local translation in dendrites for creating these essential memory proteins.

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cell Biology

Background:

  • Long-term memory (LTM) formation is dependent on new protein synthesis.
  • The precise location of this protein synthesis is an active area of research.

Purpose of the Study:

  • To review experimental evidence supporting local protein synthesis in neuronal dendrites.
  • To identify outstanding questions regarding dendritic local translation in memory.

Main Methods:

  • Review of existing experimental studies on protein synthesis and memory.
  • Analysis of data related to neuronal plasticity and dendritic translation.

Main Results:

  • Growing evidence supports the hypothesis of local protein synthesis within neuronal dendrites.
  • Specific proteins synthesized locally are implicated in synaptic plasticity and memory consolidation.

Conclusions:

  • Local translation in dendrites is a significant mechanism contributing to long-term memory.
  • Further research is needed to fully elucidate the molecular players and regulatory mechanisms involved.