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Published on: February 4, 2015
In utero losartan withdrawal and subsequent development of fetal inferior vena cava thrombosis
Jamie N Bakkum1, Brian C Brost, Keith L Johansen
1Section of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA.
Background:
Angiotensin receptor blockers are antihypertensive medications prescribed by a wide variety of physicians, especially for patients with coexistent diabetes mellitus. Angiotensin receptor blockers, as well as angiotensin-converting enzyme inhibitors, are contraindicated in pregnancy.
Case:
We describe the reversal of losartan-induced oligohydramnios at 27 weeks of gestation with subsequent development of fetal thrombosis and possible mechanism of action for this extremely rare in utero complication.
Conclusion:
This theory may help explain the fetal stillbirths in women taking this class of medications during the second and third trimester of pregnancy.
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