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Updated: Jul 19, 2026

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells

Published on: September 12, 2019

Adenosarcoma arising in inguinal endometriosis.

Michael R Milam¹, James B Atkinson, John L Currie

¹Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Vanderbilt University, Nashville, TN, USA. mrmilam@mdanderson.org

Obstetrics and Gynecology

|October 5, 2006

Summary

Adenosarcoma in inguinal endometriosis is rare. Consider this diagnosis in patients with endometriosis history and estrogen therapy presenting with a groin mass.

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Area of Science:

Gynecologic Oncology
Surgical Pathology

Background:

Inguinal endometriosis-associated adenosarcoma is a rare clinical occurrence.
Endometriosis is a condition where endometrial-like tissue exists outside the uterus.

Observation:

A 47-year-old nulligravida presented with a large, persistent right groin mass.
The patient had a history of total abdominal hysterectomy and bilateral salpingo-oophorectomy for endometriosis 16 years prior.
She had been on continuous estrogen therapy post-surgery.

Findings:

Surgical excision revealed a 12 x 4 cm inguinal mass.
Histopathological examination confirmed adenosarcoma arising within endometriosis.

Implications:

This case highlights the importance of considering adenosarcoma in the differential diagnosis of groin masses.

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Last Updated: Jul 19, 2026

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells

Published on: September 12, 2019

Patients with a history of endometriosis and unopposed estrogen therapy are at risk.

Early recognition and diagnosis are crucial for appropriate management.