Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gene control by large noncoding RNAs.

Ilya Shamovsky1, Evgeny Nudler

  • 1Department of Biochemistry, New York University Medical Center, New York, NY 10016, USA.

Science'S STKE : Signal Transduction Knowledge Environment
|October 5, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>Porphyromonas gingivalis</i> secreted factors drive epithelial-mesenchymal transition (EMT) through gingipains and an H<sub><b>2</b></sub>S-mediated bacterial defense system.

Gut microbes·2026
Same author

ZCWPW1 organizes telomeric architecture to drive meiotic chromosome movements.

bioRxiv : the preprint server for biology·2026
Same author

Author Correction: Unravelling cysteine-deficiency-associated rapid weight loss.

Nature·2025
Same author

Collateral sensitivity and genetic vulnerability of antibiotic resistance.

Trends in microbiology·2025
Same author

Molecular basis for noncanonical transcription initiation from Np<sub>4</sub>A alarmones.

Nature chemical biology·2025
Same author

Elementary 3D organization of active and silenced E. coli genome.

Nature·2025
Same journal

Identification of redox-active cell-surface proteins by mechanism-based kinetic trapping.

Science's STKE : signal transduction knowledge environment·2007
Same journal

Image correlation spectroscopy.

Science's STKE : signal transduction knowledge environment·2007
Same journal

Studies of SARM1 uncover similarities between immune and neuronal responses to danger.

Science's STKE : signal transduction knowledge environment·2007
Same journal

A discrete signaling function for an inositol pyrophosphate.

Science's STKE : signal transduction knowledge environment·2007
Same journal

Putting on the RITz.

Science's STKE : signal transduction knowledge environment·2007
Same journal

Type I interferons as anti-inflammatory mediators.

Science's STKE : signal transduction knowledge environment·2007
See all related articles

Large noncoding RNAs (lncRNAs) like Evf-2 are crucial for development. Evf-2 controls homeodomain protein expression, offering insights into organogenesis mechanisms.

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • Large noncoding RNAs (lncRNAs) are increasingly recognized for their regulatory roles in cellular processes.
  • Understanding the specific functions of lncRNAs in development is a key area of research.

Purpose of the Study:

  • To identify and characterize functional lncRNAs involved in vertebrate development.
  • To elucidate the mechanism by which Evf-2 regulates homeodomain protein expression.
  • To investigate the role of SLIRP and steroid receptor activator RNA in lncRNA-mediated gene regulation.

Main Methods:

  • Identification and functional characterization of the lncRNA Evf-2.
  • Analysis of Evf-2's role in controlling homeodomain protein expression during development.

Related Experiment Videos

  • Investigation of the interaction between Evf-2, SLIRP, and steroid receptor activator RNA.

    • Main Results:

    • Evf-2 identified as a functional lncRNA critical for vertebrate development.
    • Evf-2 demonstrated to control the expression of specific homeodomain proteins.
    • Insights provided into the cooperative mechanism involving SLIRP and steroid receptor activator RNA.

    Conclusions:

    • Evf-2 is the first identified lncRNA directly implicated in vertebrate organogenesis.
    • This study highlights the significant role of lncRNAs in developmental processes.
    • The findings offer a new perspective on gene regulation during development.