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Induced transgenerational genetic effects in rodents and humans

A T Natarajan1

  • 1Department of Toxicogenetics, Leiden University Medical Centre, Leiden, The Netherlands. natarajan@lumc.nl

Journal of Radiation Research
|October 5, 2006
PubMed

Insights

Delayed mutations appear across species, including humans, impacting future generations. This phenomenon, particularly transgenerational tumor induction in mice, highlights significant genetic effects.

Area of Science:

  • Genetics and Molecular Biology
  • Developmental Biology
  • Toxicology

Background:

  • Delayed appearance of induced mutations is a recognized phenomenon across diverse organisms.
  • Pioneering work demonstrated transgenerational tumor induction in mice following mutagen exposure.
  • The significance of delayed genetic effects is increasingly understood.

Purpose of the Study:

  • To review the literature on transgenerational genetic effects.
  • To focus on chromosomal aberrations and mutations.
  • To cover findings in rodents and humans.

Main Methods:

  • Literature review of scientific publications.
  • Analysis of studies on induced mutations and chromosomal aberrations.
  • Synthesis of data from rodent and human studies.

Main Results:

  • Delayed mutation appearance is documented in Drosophila, plants, rodents, and humans.
  • Transgenerational tumor induction in mice is a key example of these effects.
  • The review consolidates evidence on genetic alterations across generations.

Conclusions:

  • Delayed genetic effects, including mutations and chromosomal aberrations, are significant across species.
  • Transgenerational impacts of mutagens warrant further investigation.
  • Understanding these delayed effects is crucial for human health and genetic risk assessment.

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