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Related Experiment Video

Updated: Jul 19, 2026

Determining heat and mechanical pain threshold in inflamed skin of human subjects
13:21

Determining heat and mechanical pain threshold in inflamed skin of human subjects

Published on: January 14, 2009

Inflammatory pain: kinins and antagonists.

J B Calixto1, D A Cabrini, J Ferreira

  • 1Department of Pharmacology, Center of Biological Sciences, Universidade Federal de Santa Catarina, 88015-420 Florianópolis, Santa Catarina, Brazil. calixto@farmaco.ufsc.br

Current Opinion in Anaesthesiology
|October 5, 2006
PubMed
Summary

Kinins are key mediators of inflammatory pain. Research highlights their role in pain responses, with B(1) and B(2) receptors being crucial, especially B(1) in chronic pain.

Related Experiment Videos

Last Updated: Jul 19, 2026

Determining heat and mechanical pain threshold in inflamed skin of human subjects
13:21

Determining heat and mechanical pain threshold in inflamed skin of human subjects

Published on: January 14, 2009

Area of Science:

  • Pharmacology
  • Pain Research
  • Molecular Biology

Background:

  • Kinins are peptides increasingly recognized as mediators of inflammatory pain.
  • They are produced in response to noxious stimuli and act as algogens.

Purpose of the Study:

  • To review recent findings in kinin research.
  • To elucidate the role of kinins and their receptors in pain.

Main Methods:

  • Pharmacological approaches.
  • Molecular approaches.
  • Studies using selective kinin antagonists.
  • Receptor gene deletion technology.

Main Results:

  • Both B(1) and B(2) kinin receptors play significant roles in nociceptive responses.
  • The B(1) receptor is particularly important in chronic inflammatory pain stages.

Conclusions:

  • Kinins are vital mediators in inflammatory pain.
  • Targeting kinin receptors, especially B(1) selective antagonists, holds therapeutic potential for pain management.