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Use of a Low-flow Digital Anesthesia System for Mice and Rats
08:06

Use of a Low-flow Digital Anesthesia System for Mice and Rats

Published on: September 7, 2016

Cost-effectiveness of anaesthesia

D Kettler1, T Crozier

  • 1Department of Anaesthesiology, Emergency Medicine and Intensive Care, Georg August University, Göttingen, Germany. dkettle@gwdg.de

Current Opinion in Anaesthesiology
|October 5, 2006
PubMed

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Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
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Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
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