Intra-operative use of inhaled vasodilators: are there indications?

The US Food and Drug Administration and European authorities have recently approved inhaled nitric oxide for the treatment of neonates with hypoxic respiratory failure associated with pulmonary hypertension. In addition to this highly specific condition, there is an increasing 'off-label' use of inhaled nitric oxide and other inhaled vasodilators in the perioperative setting. Potential indications include right heart failure as a result of acute pulmonary hypertension in cardiac and non-cardiac surgery, the prevention of reperfusion injury in lung transplantation, the treatment of hypoxaemia during single-lung ventilation, and more recently, the treatment of sickle cell crisis.