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A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
Published on: February 11, 2019
Determinants of drug onset
Guy L Ludbrook1, Richard N Upton
1Department of Anaesthesia and Intensive Care, University of Adelaide and Royal Adelaide Hospital, Adelaide, South Australia, Australia. guy.ludbrook@adelaide.edu.au
Current Opinion in Anaesthesiology
|October 5, 2006
Summary
Drug delivery factors significantly impact drug onset timing and intensity. Understanding these variables is crucial for optimizing drug efficacy and predicting patient response.
Area of Science:
- Pharmacology
- Drug Delivery Systems
- Pharmacokinetics
Background:
- Drug onset is influenced by the entire drug delivery pathway.
- Variability in drug response necessitates understanding these influencing factors.
Purpose of the Study:
- To review recent evidence on factors affecting drug delivery and their impact on drug onset.
- To examine the significance of these factors in clinical practice.
Main Methods:
- Literature review of recent evidence.
- Analysis of physiological and formulation-related factors.
Main Results:
- Drug formulations, coadministration, and physiological variables like cardiac output significantly affect drug onset.
- Blood flow to target organs and lung function also play a role.
- Variability at the target site, including receptor interactions, impacts drug onset profiles.
Conclusions:
- Factors within the drug delivery chain demonstrably influence drug onset and response variability.
- Further research is needed to integrate these findings into dosing guidelines and predictive models.
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