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A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis
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Aggregating the amyloid Abeta(11-25) peptide into a four-stranded beta-sheet structure

Geneviève Boucher1, Normand Mousseau, Philippe Derreumaux

  • 1Département de Physique and Centre Robert-Cedergren en bioinformatique, Université de Montréal, C.P. 6128, Succursale Centre-ville Montréal, Québec H3C 3J7, Canada.

Proteins
|October 5, 2006
PubMed
Summary

Amyloid beta (Abeta) peptide aggregation into beta-sheets is accelerated by preformed dimers. The reptation mechanism aids structural reorganization without full dissociation during Abeta(11-25) monomer aggregation.

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