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Suppression of type II collagen-induced arthritis by monoclonal antibodies
S Kobayashi1, K Terato, Y Harada
1Tsukuba Research Laboratories, Esai Co., Ibaraki, Japan.
Arthritis and Rheumatism
|January 1, 1991
Abstract:
Some mouse monoclonal antibodies raised against chicken type II collagen suppressed or delayed the onset of chicken type II collagen-induced arthritis in DBA/1 mice. This was correlated with the suppression of anti-mouse type II collagen antibody responses following immunization with chicken type II collagen. The epitopes recognized by the suppressive antibodies were found to be present on cyanogen bromide (CB)-digested collagen peptides CB-11 and CB-12. This was also confirmed by the finding that administration of the CB-11 or CB-12 peptide suppressed the induction of arthritis.