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Synthesis and antiproliferative activity in vitro of diacetylenic thioquinolines
W Mól1, A Naczyński, S Boryczka
1Department of Organic Chemistry, The Medical University of Silesia, Sosnowiec, Poland.
Abstract:
A series of new acetylenic thioquinolines containing propargyl, 2-butynyl, or 4-bromo-2-butynyl groups has been prepared and tested for antiproliferative activity in vitro against the cells of human [SW707 (colon cancer), CCRF/CEM (leukemia)] and murine [P388 (leukemia), B16 (melanoma)] cancer lines. All the compounds obtained exhibited antiproliferative activity. The most active compounds 4h and 41-m have ID50 values ranging from 0.2 to 3.6 microg/ml, comparable to that of the reference compound cisplatin.
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