Related Experiment Video

Updated: Jul 19, 2026

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
06:19

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

Published on: May 16, 2025

Update in the treatment of paediatric ulcerative colitis

Melanie K Greifer1, James F Markowitz

  • 1Division of Pediatric Gastroenterology and Nutrition, Schneider Children's Hospital, 269-01 76th Avenue, New Hyde Park, New York 11040, USA.

Expert Opinion on Pharmacotherapy
|October 6, 2006
PubMed

Insights

Pediatric ulcerative colitis, a chronic inflammatory bowel disease, has evolving treatment options. This review covers traditional therapies like 5-aminosalicylates and newer approaches such as biological therapy for managing this condition in children.

Area of Science:

  • Pediatric Gastroenterology
  • Inflammatory Bowel Disease Research

Background:

  • Ulcerative colitis significantly impacts the pediatric population.
  • It is a chronic inflammatory bowel disease with no current medical cure.

Purpose of the Study:

  • To review current and emerging treatment modalities for pediatric ulcerative colitis.
  • To provide an overview of therapeutic options based on advancing disease pathogenesis knowledge.

Main Methods:

  • Literature review of classical and novel treatments for pediatric ulcerative colitis.
  • Analysis of therapeutic strategies including 5-aminosalicylates, corticosteroids, immunomodulators, and biologics.

Main Results:

  • Classical treatments such as 5-aminosalicylates, corticosteroids, and immunomodulators remain foundational.
  • Biological therapies and other advanced treatments represent significant progress in managing pediatric ulcerative colitis.

Conclusions:

  • Treatment for pediatric ulcerative colitis has expanded significantly with advancements in understanding disease mechanisms.
  • A range of therapeutic options are available, from established medications to newer biological agents, offering improved management strategies.

Related Concept Videos

Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide generation. 
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents01:24

Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents

In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current medication...