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Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
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Monitoring targeted therapy: is fluorodeoxylucose uptake a marker of early response?

Hannah M Linden1, Kenneth A Krohn, Robert B Livingston

  • 1Division of Medical Oncology, School of Medicine, University of Washington Medical Center, Seattle, WA, USA. hmlinden@u.washington.edu

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|October 6, 2006
PubMed
Abstract

No abstract available in PubMed .

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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...

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