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Updated: Jul 19, 2026

Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents
Published on: May 16, 2022
Expression of calcitonin receptor-like receptor in human vascular tumours
1Institute of Physiology, Philipps-University Marburg, Marburg, Germany. hagnerbe@staff.uni-marburg.de
Background:
Vascular tumours such as Kaposi's sarcoma and capillary haemangioma are characterised by abnormal vascularisation and proliferation of endothelial cells or neoplastic cells. Adrenomedullin, a potent vasodilative peptide, and its receptor, calcitonin receptor-like receptor (CRLR), play an important part in angiogenesis.
Aim:
To establish whether this system also plays a part in vascular diseases, showing abnormal proliferation such as vascular tumours.
Methods:
CRLR expression was investigated in several specimens of Kaposi's sarcoma and other vascular tumours, using immunohistochemical analysis with a previously described CRLR-specific polyclonal antibody and reverse transcriptase-polymerase chain reaction.
Results:
Intense and specific CRLR-immunoreactive staining of neoplastic cells was observed in all specimens, which was of greater intensity than similar staining of adjacent normal endothelium.
Conclusions:
CRLR is expressed in vascular tumours and, with adrenomedullin, may have a role in neoplastic vascular growth.
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