Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Leptin resistance and obesity.

Pablo J Enriori1, Anne E Evans, Puspha Sinnayah

  • 1Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA.

Obesity (Silver Spring, Md.)
|October 6, 2006
PubMed
Summary

Obesity is a growing health concern. This review explores leptin resistance, a condition where the body

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bridging the gap: A biology bridging resource supporting first-year academic preparedness in higher education.

Currents in pharmacy teaching & learning·2026
Same author

Editorial: Exploring combination therapies for effective obesity and metabolic syndrome management.

Frontiers in endocrinology·2026
Same author

Effects of a single dose of psilocybin on diet-induced weight loss in obese mice.

Translational psychiatry·2026
Same author

Liraglutide and Weight Loss Among Suboptimal Responders to Metabolic Bariatric Surgery: A Randomized Clinical Trial.

JAMA network open·2025
Same author

The metabolic and cardiovascular effects of amphetamine are partially mediated by the central melanocortin system.

Cell reports. Medicine·2025
Same author

<i>Caralluma fimbriata</i> Extract Improves Vascular Dysfunction in Obese Mice Fed a High-Fat Diet.

Nutrients·2025

Area of Science:

  • Physiology
  • Endocrinology
  • Metabolic Diseases

Background:

  • Obesity presents significant human and economic burdens, necessitating improved treatments.
  • Leptin, a key hormone from adipose tissue, regulates energy balance by suppressing appetite and increasing energy expenditure.
  • Leptin resistance, characterized by impaired leptin signaling, is implicated in common obesity.

Purpose of the Study:

  • To review the evidence for leptin resistance in both human obesity and animal models.
  • To explore the potential underlying mechanisms contributing to leptin resistance.

Main Methods:

  • Literature review of studies investigating leptin's role in energy homeostasis.
  • Analysis of evidence from mouse models of obesity and human clinical data.
  • Examination of proposed molecular and physiological pathways involved in leptin resistance.

Main Results:

  • Evidence supports the existence of leptin resistance in various models of obesity.
  • Leptin signaling pathways appear to be disrupted, leading to a loss of appetite control and reduced energy expenditure.
  • Multiple potential mechanisms contribute to the development of leptin resistance.

Conclusions:

  • Leptin resistance is a significant factor in the pathophysiology of common obesity.
  • Further research into the mechanisms of leptin resistance is crucial for developing effective anti-obesity therapies.

Related Experiment Videos