Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Blood substitutes.

Fahim A Habib1, Stephen M Cohn

  • 1Department of Surgery, University of Miami School of Medicine, Miami, Florida 33101, USA.

Current Opinion in Anaesthesiology
|October 6, 2006
PubMed
Summary
This summary is machine-generated.

Oxygen therapeutics, like hemoglobin solutions and perfluorochemicals, offer alternatives to blood transfusions. Understanding their distinct effects and risks is crucial for optimal clinical use in various patient populations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is the Vermiform Appendix A "Safe House?": A Preliminary Examination of the Appendix Microbiome.

Shock (Augusta, Ga.)·2026
Same author

Faecaliths do not predict severity of acute appendicitis.

The British journal of surgery·2022
Same author

Inferior Vena Cava Filters Lack Benefit in High-Risk Trauma Patients.

The American surgeon·2022
Same author

Emergency Ileostomies in Older Patients.

The American surgeon·2022
Same author

A CT-Derived Measurement of Sarcopenia Fails to Predict Falls.

The American surgeon·2022
Same author

Evaluating the Reliability of Transcranial Doppler Ultrasonography in Healthy Normal Adults.

The American surgeon·2021
Same journal

The evolution of nonoperating room anesthesia: navigating a new frontier.

Current opinion in anaesthesiology·2026
Same journal

Enhanced recovery pathways for patients with chronic pain: beyond standard protocols - a narrative review.

Current opinion in anaesthesiology·2026
Same journal

Novel technologies and innovations in postoperative follow-up after regional anesthesia.

Current opinion in anaesthesiology·2026
Same journal

Regional anaesthesia and analgesia in surgical patients with chronic preoperative pain: mechanisms, evidence, and clinical implications.

Current opinion in anaesthesiology·2026
Same journal

Retention in pain care and research: a narrative review focused on implanted medical devices.

Current opinion in anaesthesiology·2026
Same journal

Airway ultrasound in patients undergoing head and neck surgery.

Current opinion in anaesthesiology·2026
See all related articles

Area of Science:

  • Biomedical Engineering
  • Pharmacology
  • Emergency Medicine

Background:

  • Research into oxygen therapeutics is driven by risks of disease transmission and transfusion limitations in prehospital and combat settings.
  • Several oxygen-carrying products have completed safety trials and are under efficacy investigation.
  • Clinicians may soon use these agents for diverse patient populations, necessitating an understanding of their unique physiological effects.

Purpose of the Study:

  • To provide an overview of recent developments in oxygen therapeutics.
  • To highlight clinical trial results of various oxygen-carrying agents.
  • To inform optimal clinical utilization by detailing benefits and shortcomings.

Main Methods:

  • Review of clinical trial data for hemoglobin-based oxygen carriers (HBOCs) and perfluorochemicals (PFCs).

Related Experiment Videos

  • Analysis of safety profiles, efficacy, and physiological effects of different oxygen therapeutic agents.
  • Assessment of current research and development in novel oxygen carrier technologies.

    • Main Results:

    • Bovine and human hemoglobin solutions and PFC emulsions are in advanced clinical testing.
    • Bovine HBOCs show potential but require larger safety trials due to vascular reactivity and antibody formation.
    • Polymerized human HBOCs demonstrate a favorable safety profile and resuscitation efficacy but face substrate limitations; PFCs reduce transfusion needs but require high inspired oxygen.

    Conclusions:

    • Oxygen carriers present a viable alternative to allogeneic blood transfusions.
    • Clinical equivalence among oxygen therapeutic agents is not established; distinct profiles exist.
    • Optimal use demands thorough comprehension of each agent's therapeutic potential and adverse effects.