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[Immunohistochemistry and the sweat glands]
J Arrese Estrada1, G E Pierard
1Servicio de Dermatologia, CHU du Sart Tilman, Liège, Bélgica.
Medicina Cutanea Ibero-Latino-Americana
|January 1, 1990
Summary
This study identifies specific antibodies that highlight the distinct immunohistological features of eccrine and apocrine sweat glands, aiding in their differentiation.
Area of Science:
- Dermatology
- Histology
- Immunohistochemistry
Context:
- Eccrine and apocrine sweat glands are crucial skin appendages with distinct functions and morphologies.
- Understanding their unique immunohistological profiles is essential for accurate diagnosis and research.
- Previous characterization of sweat gland markers has been incomplete.
Purpose:
- To delineate the specific immunohistological markers for eccrine and apocrine sweat glands.
- To differentiate between eccrine and apocrine sweat gland structures using a panel of antibodies.
- To establish reliable immunohistochemical markers for the acrosyringium.
Summary:
- Antibodies against cytokeratins 6 and 18 stained eccrine glands, excluding the acrosyringium.
- Anti-CEA antibody uniformly stained eccrine glands.
- Antibodies to cytokeratins 8, 18, and 19 labeled apocrine glands and the eccrine secretory portion.
- Anti-EMA antibody identified the acrosyringia.
- Anti-S-100 protein was positive in the eccrine secretory portion.
Impact:
- Provides a detailed immunohistological map for distinguishing eccrine and apocrine sweat glands.
- Enhances diagnostic accuracy in skin biopsies involving sweat gland abnormalities.
- Offers valuable tools for future research into sweat gland development and diseases.