Related Experiment Video

Updated: Jul 19, 2026

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy
11:27

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Published on: April 29, 2014

[Managing the side effects of angiogenetic inhibitors in metastatic renal cell carcinoma]

M Staehler1, N Haseke, G Schöppler

  • 1Urologische Klinik und Poliklinik der Ludwig-Maximilians-Universität, Klinikum Grosshadern, Marchioninistrasse 15, 81377, München, Germany. michael.staehler@med.uni-muenchen.de

Der Urologe. Ausg. A
|October 6, 2006
PubMed

Insights

Sunitinib and Sorafenib are effective renal cell carcinoma treatments, but side effects often interrupt therapy. Prophylaxis can prevent or reduce these side effects, allowing for continuous treatment.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Sunitinib and Sorafenib are anti-angiogenic drugs used for renal cell carcinoma (RCC).
  • These drugs represent a new class of chronic therapy for RCC.
  • Chronic administration of these drugs can lead to side effects that necessitate treatment interruption.

Observation:

  • Review of published data and experience with 138 patients over 2.5 years.
  • Analysis of side effect profiles during chronic Sunitinib and Sorafenib therapy.
  • Evaluation of prophylactic strategies to manage drug-induced side effects.

Findings:

  • Side effects of Sunitinib and Sorafenib can often be prevented or mitigated through prophylactic measures.
  • Prophylaxis enables sustained application of these anti-angiogenic therapies.
  • Continuous therapy is crucial for effective management of renal cell carcinoma.

Implications:

  • Prophylactic strategies can improve treatment adherence and outcomes in renal cell carcinoma patients.
  • Managing side effects is key to maximizing the benefit of anti-angiogenic therapies.
  • This review provides practical insights for clinicians managing patients on Sunitinib and Sorafenib.

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