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Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
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Megakaryocytic blast crisis as first presentation of chronic myeloid leukemia

L Campiotti1, A M Grandi, M G Biotti

  • 1Dipartimento di Medicina Clinica Università dell'Insubria, Varese, Italy. leonardo.campiotti@uninsubria.it

American Journal of Hematology
|October 6, 2006
PubMed

We describe an extremely rare case of megakaryocytic blast crisis as first presentation of chronic myeloid leukemia. The patient had a very high platelet count and developed an ischemic stroke with seizures. She was treated with hydroxyurea, platelet apheresis, ARA-C, and idarubicin in order to obtain a prompt reduction of thrombocytosis and then with imatinib 600 mg/die PO. The therapy induced a complete hematological remission with a resolution of neurological signs within 4 weeks.

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