Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Angiogenic activity of normal and pathologic human thyroid tissue.

S A Tibblin1, I Francis

  • 1Department of Surgery, Faculty of Medicine, Kuwait.

Acta Chirurgica Scandinavica
|October 1, 1990
PubMed
Summary

Angiogenic activity in diseased thyroid tissue was assessed. Findings suggest that angiogenesis in thyroid conditions is not a reliable indicator of malignancy, even in solitary follicular neoplasms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Self-reported beta-lactam allergy in government and private hospitals in Cape Town, South Africa.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2023
Same author

Effect of Byrsocarpus Coccineus (Connaraceae) Aqueous Leaf Extract on Pancreatic Islets Volume in Type 2 Diabetic Male Wistar Rats.

Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria·2020
Same author

Splenectomy and unilateral nephrectomy complicating granulomatosis with polyangitis.

Indian journal of nephrology·2014
Same author

Editorial.

Environmental geochemistry and health·2013
Same author

Correlating the deep inferior epigastric artery branching pattern with type of abdominal free flap performed in a series of 145 breast reconstruction patients.

Annals of the Royal College of Surgeons of England·2012
Same author

Signet-ring cell adenocarcinoma of rectum with breast metastases diagnosed on FNA cytology: case report and literature review.

Cytopathology : official journal of the British Society for Clinical Cytology·2012

Area of Science:

  • Endocrinology
  • Oncology
  • Vascular Biology

Background:

  • Angiogenesis, the formation of new blood vessels, plays a critical role in both normal physiological processes and pathological conditions, including cancer.
  • The role of angiogenesis in various thyroid diseases remains an area of active investigation.
  • Understanding angiogenic capacity in thyroid neoplasms and non-neoplastic conditions is crucial for diagnosis and treatment.

Purpose of the Study:

  • To evaluate the angiogenic capacity of different types of diseased human thyroid tissues.
  • To determine if angiogenic activity can serve as a marker for thyroid malignancy.

Main Methods:

  • Thyroid tissue samples were obtained from 60 patients undergoing surgery for diverse thyroid conditions.
  • Angiogenic potential was assessed using the chick chorioallantoic membrane (CAM) assay.
  • Tissues included solitary follicular neoplasms, papillary carcinomas, Graves' disease, multinodular colloid goiter, and normal thyroid tissue.

Main Results:

  • Significant angiogenic activity was observed in 85% of solitary follicular neoplasms.
  • No angiogenic activity was detected in papillary carcinomas or normal thyroid tissue.
  • Limited angiogenic activity was noted in Graves' disease (1/7) and multinodular colloid goiter (3/17).

Conclusions:

  • Angiogenic activity in diseased human thyroid tissue is not a reliable marker for distinguishing malignant from benign conditions.
  • Solitary follicular neoplasms exhibit high angiogenic capacity, warranting further investigation.
  • The study highlights the complex role of angiogenesis in thyroid pathology.

Related Experiment Videos