Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

NK cell function in HIV-1 infection.

Galit Alter1, Marcus Altfeld

  • 1Partners AIDS Research Center, Infectious Disease Unit, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, MA 02129, USA.

Current Molecular Medicine
|October 7, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Humoral correlates of protection against <i>Mycobacterium tuberculosis</i> following intravenous BCG vaccination in rhesus macaques.

iScience·2024
Same author

Markov Field network model of multi-modal data predicts effects of immune system perturbations on intravenous BCG vaccination in macaques.

bioRxiv : the preprint server for biology·2024
Same author

Markov field network model of multi-modal data predicts effects of immune system perturbations on intravenous BCG vaccination in macaques.

Cell systems·2024
Same author

Humoral waning kinetics against SARS-CoV-2 is dictated by disease severity and vaccine platform.

medRxiv : the preprint server for health sciences·2024
Same author

Antibody-Fab and -Fc features promote <i>Mycobacterium tuberculosis</i> restriction.

bioRxiv : the preprint server for biology·2024
Same author

Measurement of circulating viral antigens post-SARS-CoV-2 infection in a multicohort study.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2024
Same journal

Corrigendum to: Sortilin as a Culprit in the Atherosclerosis Plaque Progression: Evidence from Clinical and Experimental Studies.

Current molecular medicine·2026
Same journal

Dynamic Expression of Fibroblast Activation Protein (FAP) During Chronic Pancreatitis (CP) Progression in Mice and Evaluation of FAP-targeted Tracers for Early CP Diagnosis.

Current molecular medicine·2026
Same journal

Causal Relationship Between 91 Inflammatory Factors and Gastritis: A Two-Sample Bidirectional Mendelian Randomization Study.

Current molecular medicine·2026
Same journal

Therapeutic Potential of Pistacia Atlantica Gum in Aspirin-Induced Peptic Ulcers: A Dose-Dependent Approach to Mucosal Protection and Hepatorenal Safety.

Current molecular medicine·2026
Same journal

Identification and Characterization of MicroRNAs Associated with Borax-mediated Anti-tumor Activity through High-throughput Technology.

Current molecular medicine·2026
Same journal

Broad-Spectrum Vaccines: Challenges and Opportunities (A Systematic Review).

Current molecular medicine·2026
See all related articles

Natural killer (NK) cells are key to innate immunity against viruses like HIV-1. Specific NK cell interactions, like KIR3DS1 and HLA-Bw4, may slow HIV-1 disease progression.

Area of Science:

  • Immunology
  • Virology
  • Infectious Diseases

Background:

  • Natural killer (NK) cells are crucial for innate immunity against infections and cancer.
  • NK cells exhibit direct antiviral activities and influence adaptive immune responses.
  • The role of NK cells in human immunodeficiency virus type 1 (HIV-1) infection is not fully understood.

Purpose of the Study:

  • To review the impact of HIV-1 infection on NK cell activity.
  • To explore the potential role of NK cells in controlling HIV-1 disease.
  • To synthesize current literature on NK cells and HIV-1 pathogenesis.

Main Methods:

  • Literature review of studies on NK cell activity in HIV-1 infection.
  • Analysis of research on NK cell receptors and their ligands in HIV-1.

Related Experiment Videos

  • Examination of data linking NK cell subsets to disease progression.

    • Main Results:

    • Recent findings associate NK cell receptor KIR3DS1 with its ligand HLA-Bw4 (isoleucine at position 80) with slower HIV-1 progression.
    • This suggests a significant role for NK cells in managing HIV-1 infection.
    • HIV-1 infection affects NK cell activity, but the precise mechanisms require further investigation.

    Conclusions:

    • NK cells are implicated in controlling HIV-1 infection.
    • Further research into NK cell function is vital for understanding HIV-1 pathogenesis.
    • Targeting NK cell pathways may offer therapeutic strategies for HIV-1.