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ApoE genotype and cognition after subarachnoid haemorrhage: a longitudinal study
A-M Louko1, J Vilkki, T Niskakangas
1Department of Neurosurgery, Helsinki University Central Hospital, Helsinki, Finland. anna-maria.louko@hel.fi
Objectives:
To investigate the effect of the apolipoprotein epsilon4 allele on cognitive functions after aneurysmal subarachnoid haemorrhage (SAH) in a longitudinal study.
Materials And Methods:
Performances of 19 patients with and 27 patients without the epsilon4 allele were compared on eight cognitive test variables measured 1-4.5 years and 12-15 years after SAH.
Results:
In the baseline examination, epsilon4 patients scored worse than non-epsilon4 patients on verbal fluency (P < 0.05). In the follow-up, a visual memory task and interference in colour naming showed more pronounced impairments from baseline in epsilon4 carriers than in non-carriers.
Conclusion:
Presence of the epsilon4 allele poses a minor risk for late cognitive impairment after the subacute phase of aneurysmal SAH.
