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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
ACE I/D polymorphism in different etiologies of ischemic stroke
1Department of Neurology, Jagiellonian University, Krakow, Poland. pera@su.krakow.pl
Acta Neurologica Scandinavica
|October 7, 2006
Summary
This study found no association between the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and ischemic stroke (IS) subtypes in the Polish population. The ACE I/D polymorphism did not appear to be a risk factor for different ischemic stroke etiologies.
Area of Science:
- Genetics
- Neurology
- Cardiovascular Science
Background:
- Inconsistent data exist regarding the association between angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and ischemic stroke (IS).
- Some studies suggest the DD genotype may increase the risk for small vessel disease (SVD) stroke.
- The role of ACE I/D polymorphism in IS of various etiologies requires further investigation.
Purpose of the Study:
- To investigate the association between ACE I/D polymorphism and different etiological subtypes of ischemic stroke in a Polish population.
- To clarify the potential role of ACE I/D polymorphism as a risk factor for specific ischemic stroke subtypes, including large vessel disease, SVD, and cardioembolic stroke.
Main Methods:
- Ischemic stroke etiology was classified using the TOAST criteria.
- Case-control study design involving stroke patients (large vessel disease, SVD, cardioembolic stroke) and matched controls.
- ACE I/D polymorphism was genotyped using the polymerase chain reaction (PCR) method.
Main Results:
- No significant differences in the distribution of ACE genotypes and alleles were observed between ischemic stroke subtypes and their respective matched controls.
- The analysis included 92 large vessel disease stroke patients, 96 SVD stroke patients, and 180 cardioembolic stroke patients.
- Genotype and allele frequencies for ACE I/D polymorphism were consistent across all investigated etiological subtypes of IS.
Conclusions:
- This study did not find a statistically significant association between the ACE I/D polymorphism and etiological subtypes of ischemic stroke in the studied Polish population.
- The ACE I/D polymorphism is unlikely to be a major genetic risk factor for large vessel disease, SVD, or cardioembolic stroke in this population.
- Further research with larger and diverse populations may be warranted to definitively establish or refute the link between ACE polymorphism and ischemic stroke.
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