Treatment in the pediatric emergency department is evidence based: a retrospective analysis

Kellie L Waters1, Natasha Wiebe, Kristie Cramer

  • 1Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada. kelliewaters@cha.ab.ca

BMC Pediatrics
|October 7, 2006
PubMed

Insights

Most pediatric emergency department treatments are evidence-based, primarily using pediatric studies. A significant number of patients in the pediatric emergency department receive no intervention.

Area of Science:

  • Pediatric Emergency Medicine
  • Evidence-Based Practice
  • Clinical Decision-Making

Background:

  • Assessing the evidence base for pediatric emergency department (PED) treatment decisions.
  • Determining the proportion of evidence originating from pediatric-specific studies.

Purpose of the Study:

  • To quantify the evidence supporting treatment decisions in a pediatric emergency department.
  • To ascertain the percentage of evidence for PED treatments derived from pediatric research.

Main Methods:

  • Retrospective chart review of randomly selected patients in a PED (2002).
  • Identification of primary diagnosis and intervention for each patient.
  • Literature search for randomized control trials (RCTs) or systematic reviews to classify evidence levels (Level I, II, III).

Main Results:

  • 80.4% of 168 assessed interventions were evidence-based (Level I).
  • 83.7% of evidence-based interventions were supported by studies predominantly involving pediatric patients.
  • 35.9% of patients received no primary intervention.

Conclusions:

  • A substantial proportion of pediatric emergency department treatment decisions are evidence-based.
  • Most evidence supporting PED treatments comes from pediatric patient studies.
  • A significant number of pediatric emergency department patients do not receive an intervention.
Abstract

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...