Related Experiment Video
Updated: Jul 19, 2026
Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
Published on: March 5, 2022
Validation of a prediction model for the follicle-stimulating hormone response dose in women with polycystic ovary
Madelon van Wely1, Bart C J M Fauser, Joop S E Laven
1Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. m.vanwely@amc.uva.nl <m.vanwely@amc.uva.nl>
Objective:
To validate a published model for the prediction of the individual FSH response dose for gonadotropin induction of ovulation in polycystic ovary syndrome (PCOS).
Design:
Structured, complete, and carefully monitored patient-based data collection to test the external validity of the prediction model.
Setting:
Twenty-nine hospitals in The Netherlands.
Patient(S):
Eighty-five clomiphene citrate (CC)-resistant women with PCOS.
Intervention(S):
Ovulation induction in a chronic low-dose step-up FSH regimen.
Main Outcome Measure(S):
Predicted individual FSH response dose, defined as follicle growth >10 mm in diameter on ultrasound.
Result(S):
The model, using the women's body mass index, CC response, initial serum FSH level, and initial serum insulin-to-glucose ratio was studied in the validation sample. Overall, the FSH response dose predicted by the model was higher than the observed response dose. The predictive performance of the model was poor, with an R(2) of 0.11, and the average prediction error was 35 IU.
Conclusion(S):
The external validity of the model predicting the individual FSH response dose was inadequate in women with CC-resistant PCOS undergoing ovulation induction with recombinant FSH in a low-dose step-up regimen.
Related Concept Videos
01:30Hormonal Control of the Ovarian Cycle
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
01:27Ovarian Cycle
02:07Oogenesis
01:22Hormonal Regulation of the Menstrual Cycle
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.