Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Surface-textured PEG-based hydrogels with adjustable elasticity: Synthesis and characterization.

Pascal M Pfister1, Michael Wendlandt, Peter Neuenschwander

  • 1Department of Materials, ETH Zurich, CH-8093 Zurich, Switzerland.

Biomaterials
|October 7, 2006
PubMed
Summary

Researchers developed tunable poly(ethylene glycol)-dimethacrylate (PEGDMA) hydrogels with precise surface textures. These biomaterials allow controlled studies of cellular responses to substrate elasticity and topography.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predicting natural enemy efficacy in biological control using ex-ante analyses.

Scientific reports·2025
Same author

Perspective article: Food security in tropical Africa through climate-smart plant health management.

Heliyon·2023
Same author

Classical biological of key horticultural pests in Africa: successes, challenges, and opportunities.

Current opinion in insect science·2022
Same author

Continental-scale suppression of an invasive pest by a host-specific parasitoid underlines both environmental and economic benefits of arthropod biological control.

PeerJ·2018
Same author

[Spontaneous and induced metamorphosis inXenopus larvae at low temperature].

Wilhelm Roux' Archiv fur Entwicklungsmechanik der Organismen·2017
Same author

Synthesis, characterization and histomorphometric analysis of cellular response to a new elastic DegraPol® polymer for rabbit Achilles tendon rupture repair.

Journal of tissue engineering and regenerative medicine·2012

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Surface Engineering

Background:

  • Developing advanced biomaterials is crucial for understanding cell-material interactions.
  • Controlling hydrogel mechanical properties and surface topography is essential for mimicking biological environments.

Purpose of the Study:

  • To create poly(ethylene glycol)-dimethacrylate (PEGDMA)-based hydrogels with tunable mechanical properties and micro-scale surface textures.
  • To investigate the swelling behavior and its implications for precise texture fabrication.
  • To functionalize hydrogel surfaces for biomolecule grafting.

Main Methods:

  • Synthesis of PEGDMA hydrogels with adjustable shear modulus (10 kPa to 1 MPa).
  • Fabrication of hydrogels with predefinable micro-scale surface textures.

Related Experiment Videos

  • Characterization of hydrogel swelling behavior using volume measurements.
  • Modeling swelling behavior with Flory-Huggins theory.
  • Activation of hydrogel surfaces with oxirane groups for subsequent grafting.

    • Main Results:

    • PEGDMA hydrogels exhibited minimal volume change post-fabrication and equilibration, enabling precise texture replication.
    • The swelling behavior was accurately modeled using the Flory-Huggins theory.
    • Hydrogel surfaces were successfully activated with oxirane groups, creating reactive sites for grafting.

    Conclusions:

    • PEGDMA hydrogels offer tunable elasticity and precisely controllable surface topography.
    • Their predictable swelling behavior facilitates the creation of defined surface features.
    • The reactive surface sites enable versatile biomolecule conjugation, making them ideal for cell-response studies.