Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fluctuations and membrane heterogeneity.

J R Abney1, B A Scalettar

  • 1Department of Physics, Lewis and Clark College, Portland, OR 97219, USA.

Biophysical Chemistry
|December 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hindered submicron mobility and long-term storage of presynaptic dense-core granules revealed by single-particle tracking.

Developmental neurobiology·2011
Same author

Efficient copackaging and cotransport yields postsynaptic colocalization of neuromodulators associated with synaptic plasticity.

Developmental neurobiology·2008
Same author

Real-time imaging of the dynamics of secretory granules in growth cones.

Biophysical journal·1999
Same author

Real-time imaging of the axonal transport of granules containing a tissue plasminogen activator/green fluorescent protein hybrid.

Molecular biology of the cell·1998
Same author

Chromatin dynamics in interphase nuclei and its implications for nuclear structure.

The Journal of cell biology·1997
Same author

Dispersion, aberration and deconvolution in multi-wavelength fluorescence images.

Journal of microscopy·1996
Same journal

Optimizing grid preparation methods for TEM imaging of amyloid-forming proteins.

Biophysical chemistry·2026
Same journal

Biogenic reduction mechanisms in iron oxide nanoparticle synthesis: Strategies to mitigate microbial resistance.

Biophysical chemistry·2026
Same journal

Novel Pennisetum Alopecuroides-derived activated carbon for high-efficiency Tartrazine Removal: Box-Behnken optimization and DFT-assisted mechanistic insights.

Biophysical chemistry·2026
Same journal

Reactive molecular dynamics investigation of the first steps of coronavirus (COVID-19) viral-protein ligands fragment (SARS-CoV-2).

Biophysical chemistry·2026
Same journal

Probing the interactions between bovine hemoglobin and three berberine saturated fatty acid salts by multi-spectral techniques, conductimetry and molecular docking.

Biophysical chemistry·2026
Same journal

Insights from NMR - based metabolomics elucidates key metabolic dysregulation in pancreatitis-induced acute respiratory distress syndrome: A step towards precision medicine.

Biophysical chemistry·2026
See all related articles

Biological membranes exhibit domain structures due to protein number fluctuations and interactions. These fluctuations create heterogeneity in protein distribution, influencing membrane function and dynamics.

Area of Science:

  • Biophysics
  • Cell Biology
  • Membrane Science

Background:

  • Biological membranes feature specialized domains with varying protein concentrations and compositions.
  • Understanding the origin of these domains is crucial as they influence membrane function.

Purpose of the Study:

  • To investigate how number fluctuations and interprotein interactions contribute to membrane protein distribution and domain formation.
  • To model and quantify the size and lifetime of protein-induced membrane domains.

Main Methods:

  • Modeling the membrane as a 2D fluid with interacting protein solutes.
  • Calculating characteristic domain size and lifetime based on fluctuation magnitude.
  • Generating snapshots of heterogeneity using Monte Carlo simulations.

Related Experiment Videos

Main Results:

  • Number fluctuations and interprotein forces lead to submicron-scale domain structures.
  • Domain size is influenced by interprotein forces (attractive/repulsive) and protein concentration.
  • Domain size is largest at low concentrations with attractive forces and smallest at high concentrations with repulsive forces.
  • Domain lifetime depends on size and protein diffusion coefficients.

Conclusions:

  • Protein number fluctuations and interactions are key drivers of membrane protein heterogeneity and domain formation.
  • The study provides a framework for analyzing domain structures observed in electron microscopy.
  • Results have implications for understanding membrane protein distribution and dynamics.