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Updated: Jul 19, 2026

Modeling Ligands into Maps Derived from Electron Cryomicroscopy
Published on: July 19, 2024
Map analysis of ligand binding to a linear lattice
1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Box 8231, St. Louis, MO 63110, USA.
Abstract:
A one-dimensional mapping of the binding properties of a linear lattice offers an exact analytical solution for the site-specific properties of the lattice once the length N and the parameter for nearest neighbor interactions are specified. The solution is derived independent of the definition of the partition function or the transfer matrix, nor does it involve combinatorial arguments. This result provides a simple and effective way of analyzing experimental data for protein-ligand interactions and broadens our understanding of site-specific properties in biological macromolecules.
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