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Does ethamsylate reduce haemorrhage in transurethral prostatectomy?
British Journal of Urology
|December 1, 1990
Summary
Ethamsylate (Dicynene) did not reduce blood loss in patients undergoing transurethral prostatectomy. This randomized trial found no significant benefit during or after the surgical procedure.
Area of Science:
- Urology
- Surgical Hemostasis
- Pharmacology
Background:
- Transurethral prostatectomy is a common surgical procedure.
- Minimizing blood loss during and after surgery is crucial for patient outcomes.
- Ethamsylate (Dicynene) is a hemostatic agent sometimes used to control bleeding.
Purpose of the Study:
- To evaluate the efficacy of ethamsylate (Dicynene) in reducing blood loss during transurethral prostatectomy.
- To determine if ethamsylate has a significant impact on operative and post-operative bleeding.
Main Methods:
- A double-blind, randomized controlled trial was conducted.
- 44 consecutive patients undergoing transurethral prostatectomy were included.
- Patients received either ethamsylate or a placebo, with blood loss meticulously measured.
Main Results:
- Ethamsylate did not significantly reduce blood loss compared to placebo.
- No difference in operative blood loss was observed.
- Post-operative blood loss was also not significantly affected by ethamsylate administration.
Conclusions:
- Ethamsylate (Dicynene) is not effective in reducing blood loss associated with transurethral prostatectomy.
- The use of ethamsylate for hemostasis in this surgical context is not supported by this trial's findings.