Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Internal axonal cytoarchitecture is shaped locally by external compressive forces.

R L Price1, R J Lasek, M J Katz

  • 1Bio-architectonics Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106.

Brain Research
|October 22, 1990
PubMed
Summary

Axon structure varies along avian myelinated nerves. Neurofilament density increases in regions with external compression, like Schwann cell nuclei and nodes of Ranvier, indicating mechanical forces shape nerve architecture.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Context-specific functions of Notch in Drosophila blood cell progenitors.

Developmental biology·2020
Same author

Ammoniation of Whole Cottonseed at Atmospheric Pressure and Ambient Temperature to Reduce Aflatoxin M<sub>1</sub> in Milk <sup>1</sup>.

Journal of food protection·2019
Same author

In vitro and in vivo properties of the bovine antimicrobial peptide, Bactenecin 5.

PloS one·2019
Same author

Hydroxylation and translational adaptation to stress: some answers lie beyond the STOP codon.

Cellular and molecular life sciences : CMLS·2016
Same author

Determining the structural stability of UiO-67 with respect to time: a solid-state NMR investigation.

Chemical communications (Cambridge, England)·2016
Same author

The Statistical Modeling of Aging and Risk of Transition Project: Data Collection and Harmonization Across 11 Longitudinal Cohort Studies of Aging, Cognition, and Dementia.

Observational studies·2015

Area of Science:

  • Neuroscience
  • Cell Biology
  • Histology

Background:

  • Axon structure and myelination are crucial for nerve function.
  • Neurofilament (NF) organization within axons is thought to be influenced by mechanical forces.
  • Schwann cells form myelin sheaths and interact with axons at various histological regions.

Purpose of the Study:

  • To quantify the cross-sectional architecture of avian myelinated axons and their surrounding Schwann cells.
  • To compare neurofilament number, density, axoplasmic area, and Schwann cell area across different histological regions.
  • To investigate the relationship between external physical constraints and axonal internal architecture.

Main Methods:

  • Histological analysis of avian myelinated axons.
  • Quantification of neurofilament number, density, axoplasmic area, and Schwann cell cross-sectional area.

Related Experiment Videos

  • Comparative analysis at Schmidt-Lanterman clefts, paranodal-nodal regions, Schwann cell nuclei, and compact myelin regions.

    • Main Results:

    • Axonal areas were smaller and neurofilament densities were higher at Schmidt-Lanterman clefts, paranodal-nodal regions, and Schwann cell nuclei compared to compact myelin regions.
    • Compact myelinated regions showed lower neurofilament packing density and larger axon diameters, suggesting minimal external constraints.
    • A gradient of increasing external compressive effects was observed: compact myelin < Schwann cell nucleus < S-L cleft < paranodal-nodal region.

    Conclusions:

    • Variations in Schwann cell cross-sectional areas correlate with differences in axonal architecture.
    • External constraints imposed by surrounding Schwann cell structures influence neurofilament packing density and axon diameter.
    • Physical pressure on the axon, varying across histological regions, affects its internal organization.