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Updated: Jul 19, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
Published on: March 24, 2015
Interferon-induced sarcoidosis
Mittie K Doyle1, Ruth Berggren, Jeanette H Magnus
1Centocor, Malvern, Pennsylvania PA 19355, USA. mdoyle1@cntus.jnj.com
Abstract:
Rheumatologists are increasingly asked to see patients with hepatitis C who exhibit a variety of clinical and serologic features that mimic systemic rheumatic disease. Treatment with interferons, now the standard of care, can precipitate a variety of inflammatory conditions, including sarcoidosis. We present a case of a 59-year-old former intravenous drug user who developed systemic sarcoidosis while receiving interferon alpha and ribavirin for the treatment of chronic hepatitis C. Because interferons are increasingly prescribed by specialists in a variety of disciplines, rheumatologists should be aware of their potential to induce sarcoidosis as well as various autoimmune diseases.
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