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Updated: Jul 19, 2026
Teratoma Generation in the Testis Capsule
Published on: November 7, 2011
Teratoma in an adolescent with malignant transformation into embryonal rhabdomyosarcoma: case report
David Sumerauer1, Ales Vicha, Anna Zuntova
1Department of Pediatric Hematology and Oncology, Charles University, Second Medical School, University Hospital Motol, Prague, Czech Republic. david.sumerauer@lfmotol.cuni.cz
Background:
The somatic type tumors are occasionally found in nonseminomatous germ cell tumors in men. These malignancies are presumed to arise from malignant transformation (MT) of teratoma or by differentiation of totipotential germ cell.
Observation:
A case of MT of germ cell tumor in 17-year-old male into embryonal rhabdomyosarcoma is described. The histopathologic diagnosis was that of embryonal rhabdomyosarcoma in which no germ cell elements were found. The germ cell origin of transformed histology is supported by cytogenetic analysis (isochromosome 12p), and elevated alpha(1)-fetoprotein. Despite intensive therapy the patient died.
Conclusions:
MT of teratoma is rare entity with poor prognosis.
