Neurosurgery for the treatment of epilepsy

Epilepsy is a common condition that is estimated to afflict 0.5-1.0% of the world's population. Frequently commencing in childhood, it is often associated with life-long disability. Approximately one-third of patients with epilepsy are refractory to antiepileptic drug therapy and many of these patients are candidates for surgical treatment. A growing body of evidence supports the safety and efficacy of surgery for the treatment of selected patients with epilepsy. Little information is available in the anesthesia literature regarding the presurgical assessment of candidates for surgical treatment.

The presurgical identification of suitable candidates involves a multidisciplinary approach to assessment. Recent advances, particularly in neuroimaging techniques, are dramatically enhancing the capacity to accurately identify patients who are most likely to benefit from surgery. Epilepsy surgery is underused worldwide and in developed countries. In view of current efforts to increase opportunities to provide surgical treatment to more patients and to offer surgery earlier in the course of the disorder, the number of patients requiring specialized perioperative anesthetic care is expected to increase.

This article provides anesthesiologists with an overview of the assessment process, investigation techniques and current rationale that influence the selection of appropriate candidates for surgical treatment and the associated need for specialized anesthetic care.