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Related Experiment Videos

Evolving concepts in irritable bowel syndrome.

M J Schmulson1, E A Mayer

  • 1Department of Medicine, Division of Digestive Diseases, CURE/UCLA Neuroenteric Disease Program, West Los Angeles VA Medical Center, Building 115, Room 223, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA.

Current Opinion in Gastroenterology
|October 7, 2006
PubMed
Summary
This summary is machine-generated.

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New research models irritable bowel syndrome (IBS) and functional gastrointestinal (GI) disorders by examining brain-gut interactions. This neurobiological approach considers stress responses and informs new drug development for improved quality of life.

Area of Science:

  • Neurogastroenterology
  • Neurobiology of functional gastrointestinal disorders

Background:

  • Bidirectional brain-gut interactions are central to understanding functional gastrointestinal (GI) disorders.
  • Irritable bowel syndrome (IBS) and related disorders are increasingly viewed through a neurobiological lens.

Purpose of the Study:

  • To outline a pathophysiological model for IBS and functional GI disorders based on brain-gut interactions.
  • To highlight the role of neurobiological mechanisms, including stress response pathways.

Main Methods:

  • Synthesizing evidence from peripheral and central investigations of brain-gut axes.
  • Reviewing the association between functional GI disorders and affective comorbidities.
  • Observing the impact of stressors on symptom exacerbation.

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Main Results:

  • A neurobiological model incorporating autonomic, neuroendocrine, and pain modulation alterations is emerging.
  • Alterations in central stress response mechanisms are implicated in IBS and functional GI disorders.
  • Comorbid affective disorders are frequently associated with functional GI disorders.

Conclusions:

  • The neurobiological model provides a framework for understanding IBS and related functional GI disorders.
  • Understanding brain-gut interactions and stress responses is crucial for therapeutic development.
  • Advancements in assessment tools and candidate compounds signal progress in IBS drug development.