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Celiac disease.

N Parnell1, P J Ciclitira

  • 1Gastroenterology Unit, UMDS, St. Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, UK.

Current Opinion in Gastroenterology
|October 7, 2006
PubMed
Summary
This summary is machine-generated.

Celiac disease research highlights silent cases and associated conditions. Tissue transglutaminase may play a role in pathogenesis, but T-cell activation

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Area of Science:

  • Immunology
  • Gastroenterology
  • Celiac Disease Research

Background:

  • Celiac disease research is extensive, covering screening, pathogenesis, and associated conditions.
  • High prevalence of "silent" celiac disease and its extraintestinal manifestations are noted.
  • The safety of oats in the diet is supported by new studies.

Purpose of the Study:

  • To review recent advancements in celiac disease research.
  • To highlight the role of tissue transglutaminase in disease pathogenesis.
  • To investigate the involvement of T-cell activation in celiac disease.

Main Methods:

  • Review of over 200 published papers on celiac disease.
  • Analysis of studies on "silent" celiac disease and extraintestinal manifestations.

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  • Investigation into the role of tissue transglutaminase and T-cell costimulation.

    • Main Results:

    • Tissue transglutaminase identified as a potential autoantigen enhancing gliadin peptide binding and T-cell activation.
    • Studies strengthen the case for oat safety in patients with dermatitis herpetiformis.
    • Research questions the central role of T cells through costimulation blocking studies.

    Conclusions:

    • Celiac disease research continues to expand, revealing complexities in its pathogenesis and presentation.
    • Tissue transglutaminase emerges as a key factor, influencing T-cell responses.
    • Further research is needed to fully elucidate the role of T cells in celiac disease.