Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute liver failure.

R J Fontana1

  • 1University of Michigan Medical Center, Ann Arbor, Michigan, USA.

Current Opinion in Gastroenterology
|October 7, 2006
PubMed
Summary
This summary is machine-generated.

Hepatitis A vaccination prevents severe liver failure. New causes and treatments for acute liver failure are emerging, but liver transplantation remains the primary survival strategy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The higher prevalence of truncal obesity and diabetes in American than Chinese patients with chronic hepatitis C might contribute to more rapid progression to advanced liver disease.

Alimentary pharmacology & therapeutics·2017
Same author

Good for the lung but bad for the liver? Garlic-induced hepatotoxicity following liver transplantation.

Journal of clinical pharmacy and therapeutics·2017
Same author

The Natural History of Severe Acute Liver Injury.

The American journal of gastroenterology·2017
Same author

Editorial: hepatocellular carcinoma--a rare complication of hepatic venous outflow tract obstruction.

Alimentary pharmacology & therapeutics·2015
Same author

Comparative analysis of portal hepatic infiltrating leucocytes in acute drug-induced liver injury, idiopathic autoimmune and viral hepatitis.

Clinical and experimental immunology·2014
Same author

Changes in characteristics of hepatitis C patients seen in a liver centre in the United States during the last decade.

Journal of viral hepatitis·2014

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Transplantation Medicine

Background:

  • Severe hepatitis A infection is a recognized cause of acute liver failure, preventable by vaccination.
  • Emerging causes of acute liver failure include drug-induced liver injury (bromfenac, troglitazone), herbal remedies, and transfusion-transmitted virus.
  • Hepatitis G virus is not implicated in acute liver failure.

Purpose of the Study:

  • To review current understanding and management of acute liver failure.
  • To highlight advancements in identifying etiologies and therapeutic strategies.
  • To discuss the role of liver transplantation and novel supportive technologies.

Main Methods:

  • Literature review of acute liver failure etiologies, clinical management, and emerging therapies.

Related Experiment Videos

  • Analysis of diagnostic and prognostic markers for patient triage.
  • Evaluation of innovative treatment modalities like bioartificial liver devices and auxiliary transplantation.

    • Main Results:

    • Hepatitis A vaccination is effective in preventing severe hepatitis A-related liver failure.
    • Cerebral edema management remains challenging; hypothermia and N-acetylcysteine show promise.
    • Emergency liver transplantation is the only proven method to improve survival in acute liver failure.

    Conclusions:

    • While new causes and treatments for acute liver failure are identified, liver transplantation is the definitive therapy.
    • Improved prognostic markers and organ allocation are needed to optimize patient survival.
    • Bioartificial liver devices and auxiliary transplantation represent evolving areas of research and clinical application.