Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Esophageal cancer.

T Lerut1, G Decker

  • 1Department of Thoracic Surgery, University Hospital Gasthuisberg, Leuven, Belgium. Toni.Lerut@uz.kuleuven.ac.be

Current Opinion in Gastroenterology
|October 7, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of the introduction of an enhanced recovery pathway in esophageal cancer surgery: a cohort study and propensity score matching analysis.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2021
Same author

Esophageal stent migration leading to distal small bowel perforation.

Acta gastro-enterologica Belgica·2020
Same author

In Memoriam Professor Dr. Albert Lacquet (1904-2003).

Acta chirurgica Belgica·2018
Same author

Prognostic value of the circumferential resection margin and its definitions in esophageal cancer patients after neoadjuvant chemoradiotherapy.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2017
Same author

Isolated local recurrence or solitary solid organ metastasis after esophagectomy for cancer is not the end of the road.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2016
Same author

Neoadjuvant chemoradiation treatment followed by surgery for esophageal cancer: there is much more than the mandard tumor regression score.

Acta chirurgica Belgica·2016
Same journal

Endoscopic techniques to minimize gastroesophageal reflux during peroral endoscopic myotomy.

Current opinion in gastroenterology·2026
Same journal

Postendoscopy esophageal adenocarcinoma and neoplasia: current status and future directions.

Current opinion in gastroenterology·2026
Same journal

The complement system in inflammatory bowel disease: from early observations to emerging frontiers.

Current opinion in gastroenterology·2026
Same journal

Goblet cell-associated antigen passages in health and disease.

Current opinion in gastroenterology·2026
Same journal

Inflammatory bowel diseases 2026: form, function and therapeutic considerations for the epithelial barrier.

Current opinion in gastroenterology·2026
Same journal

Dietary protein as a regulator of colitis and colorectal cancer.

Current opinion in gastroenterology·2026
See all related articles

Esophageal cancer remains aggressive. Advances in detection and molecular biology offer new hope for improved diagnosis and targeted therapies against this challenging disease.

Area of Science:

  • Oncology
  • Gastroenterology
  • Molecular Biology

Background:

  • Esophageal and gastroesophageal junction carcinoma is an aggressive cancer with a poor prognosis.
  • Adenocarcinoma incidence is rising, with potential risk reduction observed in nonsteroidal anti-inflammatory drug users.
  • Early detection of high-grade dysplasia and early carcinoma shows promise with 5-aminolevulinic acid (ALA) sensitization and red fluorescence.

Purpose of the Study:

  • To review current advancements in the diagnosis and treatment of esophageal and gastroesophageal junction carcinoma.
  • To highlight breakthroughs in imaging, molecular biology, and therapeutic strategies.

Main Methods:

  • Review of recent literature on esophageal carcinoma detection and treatment.
  • Discussion of advancements in imaging modalities like positron emission tomography (PET) and endoscopic ultrasound (EUS).

Related Experiment Videos

  • Exploration of molecular mechanisms including cadherins, catenins, and tumor suppressor genes (p53, p16, Rb).

    • Main Results:

    • Positron emission tomography (PET) demonstrates superiority over computed tomography (CT) in detecting distant and lymph node metastasis.
    • Endoscopic ablation shows promise for early-stage carcinoma, but EUS discrimination between Tis-T1a and T1b remains a challenge.
    • Molecular research is identifying key genes (p53, p16, Rb) involved in carcinogenesis, with potential as prognostic indicators.

    Conclusions:

    • Despite challenges, advancements in diagnostic tools and molecular understanding are paving the way for improved therapeutic strategies.
    • Targeting molecular pathways, such as restoring wild-type p53 function, may enhance treatment efficacy.
    • Further research holds promise for novel anticancer therapies for esophageal carcinoma.