Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biliary tract physiology.

R T Prall1, N F Larusso

  • 1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Medical School, and Foundation, Rochester, Minnesota 55905, USA.

Current Opinion in Gastroenterology
|October 7, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interactions between chronic liver disease and inflammatory bowel disease.

Inflammatory bowel diseases·2013
Same author

A mouse model of autosomal recessive polycystic kidney disease with biliary duct and proximal tubule dilatation.

Kidney international·2007
Same author

Lipopolysaccharide disrupts tight junctions in cholangiocyte monolayers by a c-Src-, TLR4-, and LBP-dependent mechanism.

American journal of physiology. Gastrointestinal and liver physiology·2007
Same author

Biliary tract physiology.

Current opinion in gastroenterology·2006
Same author

Membrane microdomains in hepatocytes: potential target areas for proteins involved in canalicular bile secretion.

Journal of lipid research·2005
Same author

ATP binding cassette transporter gene expression in rat liver progenitor cells.

Gut·2003
Same journal

Endoscopic techniques to minimize gastroesophageal reflux during peroral endoscopic myotomy.

Current opinion in gastroenterology·2026
Same journal

Postendoscopy esophageal adenocarcinoma and neoplasia: current status and future directions.

Current opinion in gastroenterology·2026
Same journal

The complement system in inflammatory bowel disease: from early observations to emerging frontiers.

Current opinion in gastroenterology·2026
Same journal

Goblet cell-associated antigen passages in health and disease.

Current opinion in gastroenterology·2026
Same journal

Inflammatory bowel diseases 2026: form, function and therapeutic considerations for the epithelial barrier.

Current opinion in gastroenterology·2026
Same journal

Dietary protein as a regulator of colitis and colorectal cancer.

Current opinion in gastroenterology·2026
See all related articles

Cholangiocytes, cells lining bile ducts, are key regulators of bile formation. New research highlights their autocrine and paracrine signaling, offering potential for novel biliary disease therapies.

Area of Science:

  • Hepatology and Gastroenterology
  • Cell Biology
  • Biliary Physiology

Background:

  • Cholangiocytes, the epithelial cells of bile ducts, were historically viewed primarily as passive conduits.
  • Recent advancements in experimental models have revealed their active role in bile formation and modulation.
  • Understanding cholangiocyte function is crucial for comprehending biliary system homeostasis.

Purpose of the Study:

  • To elucidate the mechanisms by which cholangiocytes contribute to and regulate bile formation.
  • To explore the autocrine and paracrine signaling pathways involved in biliary epithelium function.
  • To investigate novel roles of bile acids in cholangiocyte physiology and their impact on biliary diseases.

Main Methods:

  • Utilized novel experimental models to study cholangiocyte function.

Related Experiment Videos

  • Investigated fluid, solute, and electrolyte transport mechanisms across the biliary epithelium.
  • Analyzed the physiological and anatomical differences of cholangiocytes throughout the biliary tree.

    • Main Results:

    • Cholangiocytes actively contribute to and modulate bile formation through autocrine and paracrine mechanisms.
    • New roles for bile acids in cholangiocyte physiology have been identified.
    • Distinct anatomic and functional characteristics of cholangiocytes along the biliary tree have been elucidated.

    Conclusions:

    • Cholangiocytes are critical regulators of bile formation, influencing biliary physiology via local signaling.
    • Understanding cholangiocyte function and their response to injury is essential for developing new treatments for biliary diseases.