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Mucosal T-cell responses to enteric infection

H N Shi1, C Nagler-Anderson

  • 1Mucosal Immunology Laboratory, Combined Program in Pediatric G.I. and Nutrition, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA. shiha@helix.mgh.harvard.edu

Current Opinion in Gastroenterology
|October 7, 2006
PubMed

Although immunologists typically examine immune responses in peripheral lymphoid tissues, mucosal surfaces are the first sites at which most antigens are encountered. The role of lymphocytes in the gut-associated lymphoid tissue (GALT) in the production of secretory IgA has been well characterized. Although T cells of the GALT are located in areas likely to have a key role in cell-mediated immunity at mucosal surfaces, the ways in which these cells help defend against mucosal infection are only beginning to be understood. This review examines mucosal T-cell responses to enteric infection with bacteria, viruses, and parasites.

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