Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Carbohydrate Absorption

Carbohydrate Absorption

Carbohydrates are essential macronutrients that serve as the body's primary energy source. Their digestion begins in the mouth, where salivary amylase partially breaks down complex carbohydrates such as starch into smaller oligosaccharides. This mechanical and enzymatic activity prepares carbohydrates for further processing in the gastrointestinal tract.
After being swallowed, the partially digested carbohydrates mix with gastric secretions in the stomach. However, the acidic environment...

Protein Absorption

Protein Absorption

Proteins in the gastrointestinal tract typically come from food, but they can also originate from disintegrated cells or secreted enzymes. In the stomach, the enzyme pepsin breaks down these proteins into polypeptides. The fragments then move into the duodenum as a semi-fluid mass called chyme. Pancreatic proteases, such as trypsin and chymotrypsin, and intestinal brush border enzymes like carboxypeptidases further dismantle the polypeptides into tripeptides, dipeptides, and free amino acids.

Mineral, Vitamin and Water Absorption

Mineral, Vitamin and Water Absorption

Electrolytes are essential minerals and ions primarily obtained from the diet and absorbed through the gastrointestinal tract. Most electrolytes are absorbed in the small intestine. While the absorption of iron and calcium primarily occurs in the duodenum, calcium is also absorbed in the jejunum and ileum. In these regions, passive diffusion contributes to its absorption alongside active transport mechanisms in the duodenum. These ions can exit the enterocytes through specialized active...

Drug Absorption: Overview

Drug Absorption: Overview

The process of drug absorption signifies the transition of a drug from its site of administration into the plasma. This process is influenced by various factors, including the route of administration, the anatomy of the absorption site, the mechanism of absorption, gut motility, and the drug's physicochemical properties.
When drugs are injected intravenously, they directly enter the systemic circulation. Alternatively, orally administered drugs navigate through the gastrointestinal (GI) tract.

Factors Influencing Drug Absorption: Anatomical Parameters

Factors Influencing Drug Absorption: Anatomical Parameters

Drug absorption involves the movement of drugs from the point of administration into the systemic circulation. Initially, Gastrointestinal (GI) motility propels the drug through the digestive tract and into the stomach. However, the stomach's high acidity and limited surface area restrict its role in drug absorption for most drugs. The drug then moves from the stomach to the small intestine via gastric emptying, which can be slowed by various factors, including interactions with other...

Absorption of Nutrients

Absorption of Nutrients

Absorption refers to taking dietary nutrients from the intestinal lumen for transportation throughout the body. After digestion in the small intestine, carbohydrates, proteins, and fats are broken down into simpler forms. These essential macronutrients and other vital substances, such as vitamins, minerals, and water, are then prepared for absorption into the bloodstream.
Enterocytes, which are specialized polar epithelial cells, line the mucosa of the small intestinal walls. These cells...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The landscape of conventional and artificial intelligence-based clinical prediction models in non-small-cell lung cancer: from development to real-world validation.

ESMO open·2025

Same author

Chitosan as an environment friendly biomaterial - a review on recent modifications and applications.

International journal of biological macromolecules·2019

Same author

Effect of sintering temperature on structural and optical properties of indium(III) oxide nanoparticles prepared with Triton X-100 by hydrothermal method.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2014

Same author

Hepatocellular carcinoma: important biomarkers and their significance in molecular diagnostics and therapy.

Current medicinal chemistry·2012

Same author

Basaloid squamous cell carcinoma of retromolar trigone: A case report with review of literature.

Journal of oral and maxillofacial pathology : JOMFP·2012

Same author

Breakthrough of toluene vapours in granular activated carbon filled packed bed reactor.

Journal of hazardous materials·2009

Search research articles

Related Experiment Video

Updated: Jun 30, 2026

The Caco-2 Cell Bioassay for Measurement of Food Iron Bioavailability

The Caco-2 Cell Bioassay for Measurement of Food Iron Bioavailability

Published on: April 28, 2022

Nutrient absorption.

S A Siddiqi¹, N S Kumar, R J St Hilaire

¹Department of Medicine, Division of Gastroenterology, and Department of Physiology, University of Tennessee, Memphis, Tennessee 38163, USA.

Current Opinion in Gastroenterology

|October 7, 2006

Summary

This summary is machine-generated.

Recent advances reveal new mechanisms in nutrient absorption, including key transporters for fats, cholesterol, glucose, vitamins, and minerals. Understanding these pathways is crucial for metabolic health and disease. Keywords: nutrient absorption, transporters, metabolic health.

More Related Videos

The Isolation of Flowing Mesenteric Lymph in Mice to Quantify In Vivo Kinetics of Dietary Lipid Absorption and Chylomicron Secretion

The Isolation of Flowing Mesenteric Lymph in Mice to Quantify In Vivo Kinetics of Dietary Lipid Absorption and Chylomicron Secretion

Published on: November 30, 2022

Demonstration of Membrane Transport of Histidine using Goat Intestinal Inverted Sacs: An Experiential Pedagogical Tool for Undergraduates

Demonstration of Membrane Transport of Histidine using Goat Intestinal Inverted Sacs: An Experiential Pedagogical Tool for Undergraduates

Published on: October 4, 2024

Related Experiment Videos

Last Updated: Jun 30, 2026

The Caco-2 Cell Bioassay for Measurement of Food Iron Bioavailability

The Caco-2 Cell Bioassay for Measurement of Food Iron Bioavailability

Published on: April 28, 2022

The Isolation of Flowing Mesenteric Lymph in Mice to Quantify In Vivo Kinetics of Dietary Lipid Absorption and Chylomicron Secretion

The Isolation of Flowing Mesenteric Lymph in Mice to Quantify In Vivo Kinetics of Dietary Lipid Absorption and Chylomicron Secretion

Published on: November 30, 2022

Demonstration of Membrane Transport of Histidine using Goat Intestinal Inverted Sacs: An Experiential Pedagogical Tool for Undergraduates

Demonstration of Membrane Transport of Histidine using Goat Intestinal Inverted Sacs: An Experiential Pedagogical Tool for Undergraduates

Published on: October 4, 2024

Area of Science:

Gastroenterology and Nutrition
Molecular Biology
Physiology

Background:

Understanding nutrient absorption mechanisms is vital for addressing metabolic disorders.
Recent research has identified novel molecular players and pathways involved in nutrient uptake.

Purpose of the Study:

To summarize key advances in nutrient absorption mechanisms.
To highlight newly identified transporters and regulatory pathways.

Main Methods:

Identification of novel transport vesicles.
Characterization of receptor-mediated uptake.
Cloning and expression of nutrient transporters.
Genetic and molecular studies of regulatory proteins.

Main Results:

A novel prechylomicron transport vesicle identified as rate-limiting for triacylglycerol absorption.
Scavenger receptor BI implicated in cholesterol uptake.
Mechanisms for peptide hormone stimulation of glucose uptake elucidated.
Oligopeptide transporter (PepT1) regulation by diet, insulin, and fasting detailed.
Cloning and functional expression of SMVT, SVCT, and CaT1 transporters.
Insights into calcium absorption and vitamin D action.
Nramp2 (DMT1) identified as key regulator of nonheme iron uptake.
HFE protein's role in iron sensing and absorption defects in hemochromatosis.

Conclusions:

Significant progress has been made in elucidating the molecular mechanisms of nutrient absorption.
Identification of novel transporters and regulatory proteins offers new targets for therapeutic interventions.
Understanding these pathways is critical for managing nutritional status and related diseases.