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Novel, efficient total synthesis of natural 20(S)-camptothecin

Chao-Jun Tang1, Matej Babjak, Regan J Anderson

  • 1Chimie Recherche (LEDSS), Université Joseph Fourier, 38041 Grenoble, France.

Organic & Biomolecular Chemistry
|October 7, 2006
PubMed

Abstract:

Enantiopure 20(S)-camptothecin has been prepared from a known hydroxypyridone through a novel approach that involves a Claisen rearrangement, an asymmetric nucleophilic ethylation, a Heck coupling and a Friedländer condensation as the key transformations.

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Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
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