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Updated: Jul 19, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Novel, efficient total synthesis of natural 20(S)-camptothecin
Chao-Jun Tang1, Matej Babjak, Regan J Anderson
1Chimie Recherche (LEDSS), Université Joseph Fourier, 38041 Grenoble, France.
Abstract:
Enantiopure 20(S)-camptothecin has been prepared from a known hydroxypyridone through a novel approach that involves a Claisen rearrangement, an asymmetric nucleophilic ethylation, a Heck coupling and a Friedländer condensation as the key transformations.
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