Related Experiment Video
Updated: Jul 19, 2026

Isolation and Characterization of the Murine Uterosacral Ligaments and Pelvic Floor Organs
Published on: March 3, 2023
Biomechanical properties of prolapsed vaginal tissue in pre- and postmenopausal women
Lingling Lei1, Yanfeng Song, RiQi Chen
1Department of Obstetrics and Gynecology, Fuzhou Dongfang Hospital, Fuzhou, 350025, Fujian, People's Republic of China.
Abstract:
The aim of this study was to explore the relationship between biomechanical properties and the occurrence of pelvic organ prolapse (POP) through analysis on biomechanical properties of vaginal tissue. The biopsy specimens were obtained from 43 patients undergoing transvaginal hysterectomy, who were assigned into premenopausal POP, postmenopausal POP, premenopausal control and postmenopausal control groups. Tissue specimens were biomechanically assessed by a purpose-built tissue puller system, and stress-strain curves were digitally recorded. The Young's modulus, Poisson's ratio, maximum elongation, maximum fracture of vaginal tissue were 9.45 +/- 0.70, 0.43 +/- 0.01, 1.50 +/- 0.02, 0.60 +/- 0.02 in premenopausal POP group; 12.10 +/- 1.10, 0.39 +/- 0.01, 1.14 +/- 0.05, 0.27 +/- 0.03 in postmenopausal POP group; 6.65 +/- 1.48, 0.46 +/- 0.01, 1.68 +/- 0.11, 0.79 +/- 0.05 in premenopausal control group and 10.26 +/- 1.10, 0.42 +/- 0.01, 1.37 +/- 0.04, 0.42 +/- 0.03 in postmenopausal control group. There was significant difference in biomechanical properties between premenopausal POP group and premenopausal control group (p < 0.01). There was significant difference in biomechanical properties between postmenopausal POP group and postmenopausal control group (p < 0.01). Biomechanical properties in POP group were significantly lower than that in control group, suggesting that degeneration of biomechanical properties in pelvic support construction might lead to the occurrence of POP.
Related Concept Videos
Vagina
Microbiota of the Urogenital Tract
Muscles of the Pelvic Floor and Perineum
Perineal Layer
The perineum is a diamond-shaped area below the pelvic diaphragm, divided into an anterior urogenital triangle that contains the external genitals and a posterior anal triangle housing the anus. The urogenital...
Mitral Valve Prolapse I: Introduction
Menopause
Mitral Valve Prolapse II: Assessment and Management

