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Thrombosis and thrombophilia in children: a systematic review

Daniela Tormene1, Sabrina Gavasso, Valeria Rossetto

  • 1Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy. daniela.tormene@unipd.it

Seminars in Thrombosis and Hemostasis
|October 7, 2006
PubMed

Insights

Pediatric thrombosis is increasingly recognized, with specialized programs improving diagnosis and treatment. This review covers risk factors, prophylaxis, and thrombophilia in children, highlighting knowledge gaps due to limited pediatric trials.

Area of Science:

  • Pediatric Hematology
  • Thrombosis and Hemostasis

Background:

  • Thrombotic events in children are uncommon but increasingly recognized.
  • Advances in understanding the hemostasis system highlight the importance of thromboembolic disorders in pediatric populations.
  • Multiple underlying conditions and prothrombotic disorders contribute to childhood thrombosis.

Purpose of the Study:

  • To review current knowledge on risk factors for venous and arterial thromboembolic events in children.
  • To discuss the use of antithrombotic prophylaxis and the role of thrombophilia in pediatric patients.
  • To examine clinical manifestations and diagnostic challenges of pediatric thromboembolic and cerebrovascular diseases.

Main Methods:

  • Literature review summarizing current knowledge on pediatric thrombosis.
  • Analysis of clinical manifestations, diagnostic issues, and prophylactic strategies.
  • Discussion on the impact of prothrombotic defects and the necessity of routine testing.

Main Results:

  • Guidelines for pediatric thrombosis management often rely on adult data due to a lack of large prospective pediatric trials.
  • Specialized pediatric thrombosis programs are emerging for diagnosis, prevention, and treatment.
  • Understanding risk factors, clinical presentation, and diagnostic challenges is crucial.

Conclusions:

  • Further research and large-scale prospective trials are needed to establish evidence-based guidelines for pediatric thrombosis.
  • The role of thrombophilia testing in asymptomatic children requires careful consideration.
  • Improved understanding and management strategies are essential for addressing pediatric thromboembolic disorders.

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